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1 Study StatusRecruiting1 A clinical trial to look at how safe and effective crovalimab is in children and adolescents with atypical haemolytic uraemic syndrome (aHUS)
A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Participants With Atypical Hemolytic Uremic Syndrome (aHUS)
- Blood Disorder,
- Atypical Hemolytic Uremic Syndrome (aHUS)
- NCT04958265, BO42354, 2020-002437-15
2 Study StatusRecruiting2 A clinical trial to compare how effective and safe giredestrant plus pertuzumab and trastuzumab is compared to pertuzumab and trastuzumab with or without hormone therapy in people with locally advanced or metastatic breast cancer, with HER2 and oestrogen receptor positivity
A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer)
- Cancer,
- Oncology,
- Breast Cancer,
- Locally Advanced or Metastatic Breast Cancer,
- Estrogen Receptor (ER)-Positive,
- HER2-Positive Breast Cancer
- NCT05296798, WO43571, 2022-500014-26-00
3 Study StatusRecruiting3 A clinical trial to compare obinutuzumab with placebo in adolescents with lupus nephritis (POSTERITY)
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants
- Autoimmune Disorder,
- Lupus Nephritis
- NCT05039619, WA42985, 2021-000097-29,2023-505825-15-00
4 Study StatusActive, not recruiting4 A clinical trial to compare GDC-9545 with a doctor’s choice of hormonal therapy in people with advanced or metastatic breast cancer after previous treatment has not worked.
A Study Evaluating the Efficacy and Safety of GDC-9545 Compared With Physician's Choice of Endocrine Monotherapy in Participants With Previously Treated Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer
- Cancer,
- Breast Cancer,
- Breast Cancer Er-Positive,
- Breast Cancer HER-2 Negative,
- Locally Advanced or Metastatic Breast Cancer,
- Estrogen Receptor (ER)-Positive
- NCT04576455, WO42312, 2020-001984-10
5 Study StatusActive, not recruiting5 A study to look at how safe emicizumab treatment is and how well it works to prevent bleeds in children with haemophilia A (without factor 8 inhibitors) who started emicizumab in their first year of life
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in Participants From Birth to 12 Months of Age With Hemophilia A Without Inhibitors
- Hemophilia,
- Hemophilia A,
- Severe Hemophilia A
- NCT04431726, MO41787, 2020-001733-12,2023-505964-13-00
6 Study StatusActive, not recruiting6 A clinical trial to compare how effective and safe crovalimab is in comparison to eculizumab in people with paroxysmal nocturnal hemoglobinuria (PNH) not previously treated with complement inhibitors.
A Phase III Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors.
- Autoimmune Disorder,
- Paroxysmal Nocturnal Hemoglobinuria
- NCT04434092, BO42162, 2019-004931-21,2023-506498-36-00
7 Study StatusActive, not recruiting7 A clinical trial to compare the combination of atezolizumab plus trastuzumab emtansine versus trastuzumab emtansine in people with HER2-positive breast cancer who still have tumor tissue in the breast(s) and/or lymph nodes in the underarm area after the anti-cancer treatment received before surgery.
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
- Cancer,
- Breast Cancer,
- HER2-Positive Breast Cancer
- NCT04873362, WO42633, 2020-003681-40, 2023-503568-18-00
8 Study StatusActive, not recruiting8 A clinical trial to compare tiragolumab plus atezolizumab and bevacizumab with placebo plus atezolizumab and bevacizumab in people with untreated, advanced hepatocellular carcinoma
A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (IMbrave152)
- Cancer,
- Hepatocellular Carcinoma (HCC)
- NCT05904886, CO44668, 2023-503422-39-00
9 Study StatusActive, not recruiting9 A study to look at the effects of different treatments on rare types of previously treated epithelial ovarian, fallopian tube or primary peritoneal cancers with different molecular changes
A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
- Cancer,
- Ovarian Cancer
- NCT04931342, WO42178, GOG-3051, ENGOT-GYN2
10 Study StatusActive, not recruiting10 A study evaluating the efficacy and safety of neoadjuvant treatment with atezolizumab or placebo in combination with platinum-based chemotherapy in patients with resectable stage II, IIIA, or select IIIB non-small cell lung cancer
A Study of Neoadjuvant Atezolizumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Patients With Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer (IMpower030)
- Cancer,
- Lung Cancer,
- Non-Small Cell Lung Cancer (NSCLC)
- NCT03456063, GO40241, 2023-504209-35-00